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Always start with a lower dose to assess tolerance

Our data confirm the finding that chloroquine is an autophagy inhibitor, and is consistent with the previous autophagy modulation reported for imipramine [26], fluoxetine [27] and chlorpromazine [28] (although the authors did not specifically investigate autophagy flux in their studies)

And when it does, it no longer is able to activate the same self-renewal programs that it's able to do in the presence of connexin there

Eur J Pharmacol (2018) 828:12634

however, this is FDA staff's proposed position going into the meeting, not a final action, and the committee's discussion, any vote, and FDA's ultimate decision are still pending, so the outcome of the review is not yet known