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Considering the multifactorial nature of TMAO generation, many strategies can be pursued to reduce the level of TMA/TMAO in patients with CVDs, such as lifestyle changes, use of antibiotics and functional foods, development of related inhibitors, and improvement of gut microbiota ( Supplementary Table 4 )

2012;7(3):e33066

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10.1186/gb-2011-12-6-r60 35 ShimizuM.AllerstonC