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In this theory, reduced amounts of IGF-1 bioavailability would impact sebocyte proliferation via the loss of regulatory functions that IGF-1 has on 5-Reductase, while also causing impaired processing of secreted lipids in the interfollicular epidermis, which combined could result in the eventual keratinization of both the sebaceous gland and the impaired epithelial barrier of the follicular canal
doi: 10.1089/thy.2007.0405 34 UjhelyiBGogolakPErdeiANagyVBalazsERajnavolgyiEet al
Doch unabhngig davon, auf welchem statistischen Rang sich die einzelnen Risikofaktoren befnden, seien HbA1c, Albuminurie, Diabetesdauer, systolischer Blutdruck und LDL-C die wichtigsten Prognoseparameter, um das Risikoprofil eines Typ-1Diabetikers zu beschreiben, so die Autoren einer entsprechenden Studie (2)
Thus, current trends indicate that the prevalence of gallstone disease has doubled over the last 3 decades