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Fluid Retention and Heart Failure (Rare) Description: In rare cases, insulin therapy, including Lantus, may lead to fluid retention, which could exacerbate heart failure in susceptible individuals

Mice with FAS deleted specifically in the ARC and PVN regions of the hypothalamus exhibit reduced appetite and weigh significantly less than control animals

doi:10.1007/s11064-017-2333-6 49

* Currently treated with 1-3 oral anti diabetic drug (OADs) with stable daily doses 90 days before screening comprising any of the following anti diabetic drug(s) at effective or maximum tolerated dose

Reduced Trustworthiness: Patients need to rely heavily on the reputation and practices of the compounding pharmacy to ensure product safety