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Once vitamin C oxidizes, it loses its brightening and collagen-stimulating power

Shaking creates foam and exposes peptide molecules to air-liquid interface stress, which accelerates oxidation and aggregation

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While antioxidant systems can mitigate oxidative injury to healthy tissues during breast cancer treatment, indiscriminate use of exogenous antioxidant supplements during ROS-dependent therapies such as anthracycline chemotherapy and radiotherapy may theoretically reduce treatment efficacy by protecting malignant cells from oxidative damage