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Specific proteins reported to be upregulated in CVD (but downregulated with semaglutide treatment, after adjusting for effects of weight loss and HbA 1c reduction) include NPPB (NT-proBNP, released from cardiomyocytes on ventricular distension) 37 , ANGPT2 (involved in vascular remodeling and angiogenesis) 38 , CD93 (involved in cardiovascular homeostasis) 39 , MSR1 (involved in lipid metabolism and immune function) 40,41 , and THBS2 and TNC (both involved in extracellular matrix remodeling) 42

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suspender si se confirma embarazo No se recomienda en pacientes con gastroparesia severa Si usa insulina o sulfonilureas, puede requerir ajuste de dosis para prevenir hipoglucemia Optimizacin de la tcnica de inyeccin: Rotar los sitios de inyeccin : Alterne entre abdomen, muslo y parte superior del brazo para prevenir irritacin local Temperatura del medicamento : Deje que la pluma alcance temperatura ambiente (15-20 minutos fuera del refrigerador) antes de inyectar Tcnica apropiada : Inyecte lentamente y mantenga la presin durante 5-10 segundos despus de completar la dosis Hidratacin y nutricin: Mantener una hidratacin adecuada es crucial, especialmente si experimenta nuseas o reduccin del apetito