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Given that it has two different mechanisms of action, it appears to have a more significant effect on weight and blood sugar than GLP-1 agonist drugs alone, such as semaglutide or liraglutide, which are both currently FDA-approved for sugar and weight control under different trade names

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cAMP level can regulate the protein kinase A (PKA)-dependent activation of the cAMP response element-binding protein (CREB), which in turn upregulates the expression of PGC1 and inhibits LC3-II (Herzig and Shaw, 2018)