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Taking into account available data concerning the alkylating nature of ethylene oxide, the demonstration of DNA adducts, the overwhelming positive in vivo responses in mutagenic and clastogenic assays, the reproducible positive carcinogenic findings in animals, and the epidemiological findings suggesting an increase in the incidence of human cancer, ethylene oxide should be considered as a probable human carcinogen, and its levels in the environment should be kept as low as feasible

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This is suggestive but not demonstrative that GIPR agonism reduces the GI AE incidence associated with GLP-1R agonism

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It would also signal strong government alignment with national self-sufficiency goals in healthcare