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Subjects were excluded if they had clinically significant concomitant diseases or disorders, clinically significant abnormal values in clinical laboratory screening tests, any history of gastrointestinal surgery, had used any prescription or non-prescription drugs within 3 weeks prior to dosing of trial product (except hormone replacement therapy, contraceptives and occasional use of paracetamol in the food-effect trial), were smokers (dosing conditions trial) or were not able or willing to refrain from smoking while staying at the clinic (food-effect trial), or if they were pregnant or breastfeeding women (food-effect trial)

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Ligand binding and subsequent phosphorylation of IGF-1R triggers the activation of two major signaling cascades via the insulin receptor substrate 1 (IRS-1): the phosphatidylinositol 3-kinase/AKT kinase (PI3K/AKT) pathway and the RAF kinase/mitogen activated protein kinase (RAF/MAPK) pathway which stimulate proliferation and protection from apoptosis [11]

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10.1007/s40279-015-0393-9 Sports Med