Not only do NETs and their components (histones, DNA, and myeloperoxidase) directly damage endothelial cells, but their synergistic effects with oxLDL or native LDL further enhance endothelial-to-mesenchymal transition (EndMT), leading to endothelial cell dysfunction and promoting neovascularization, which influences AS progression [285]
Zou found that peroxisomes promoted lipid peroxidation by synthesizing polyunsaturated ether phospholipids (PUFA-ePLs), which acted as substrates for lipid peroxidation, leading to ferroptosis [77]
Without consistent healthy habits, some patients experience partial weight regain even years after surgery
OINDP stands for Orally Inhaled and Nasal Drug Products the regulatory category used by the FDA to classify both inhalation products (metered-dose inhalers, dry powder inhalers, nebulizers) and nasal drug products (nasal sprays, nasal aerosols)
As the name suggests, it involves optimising what we all spend around a third of our lives doing: sleeping