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Understanding which pathway each compound targets explains nearly every other difference between them evidence base, side effect profile, and regulatory status included

IGF-1 LR3, like native IGF-1, has a tendency to aggregate in neutral aqueous buffer

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Optic Nerve Atrophy: Administering cyanocobalamin to patients with Leber's disease or hereditary optic nerve atrophy should be done cautiously, as it may worsen the condition