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These receptors act as switches that, when activated by certain nutrients and bitter compounds, set off a cascade of hormone release (insulin) which affects metabolic processes that influence healthy weight and glucose balance, including lowering serum glucose levels and controlling appetite by delaying gastric emptying

For small molecules, this is well-established - it's the basis of nicotine patches, hormone replacement patches, and prescription pain patches

GLP-1R was initially discovered on pancreatic -cells [5, 6], highlighting GLP-1s crucial role in regulating blood sugar homeostasis