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Compared with overt Cushings syndrome, patients with MACS exhibit similar but less pronounced phenotypic features, including abdominal adiposity, dorsocervical fat accumulation, characteristic skin changes, and proximal muscle weakness [177]
In agreement with their single-drug effects, both (M+D)/2 and (M+D+V)/3 downregulated proteins linked to mitochondrial ATP synthesis and cell cycle ( Supplementary Figures S5 , S6
The relationship between B12 and weight loss success is indirect but important: energized patients exercise more consistently, build lean muscle mass during caloric restriction, and maintain psychological motivation
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