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Stopping rules: Discontinue GHK-Cu if free copper exceeds 25 mcg/dL, 24-hour urine copper exceeds 100 mcg/day, ALT or AST rises to more than 3 times the patient's baseline value, or clinical signs of copper toxicity appear

Cells deficient in FSP1 accumulate oxidized lipids within LDs, and PUFA supplementation further sensitizes these cells to ferroptotic death

Although several preclinical studies and clinical trials aimed at reducing oxidative stress using various anti-oxidant molecules have been performed (Rueda Revilla and Martnez-Cu, 2020), none of them has looked at the level of CBS expression and/or activity

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The concept of the obesity-related double burden of malnutrition has emerged with important clinical implications