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All statistical analyses were conducted using GraphPad Prism for Windows 8.0 (Graphpad Software Inc., CA, USA), SPSS Statistics 26.0 (SPSS Inc., Ill., USA), and Image J (version 1.53 K, National Institutes of Health, USA)

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I built this matrix by mapping each row to the single trial endpoint that produced the highest-quality primary evidence as of mid-2026: percent body-weight change for efficacy (Jastreboff 2023, SURMOUNT-1, STEP 1), three-point MACE for cardiovascular (SELECT), MRI-PDFF for hepatic fat (retatrutide Phase 2 sub-analyses, [unverified primary source]), and treatment-emergent adverse event rates for GI burden

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