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Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interferon-gamma (IFN-), interleukin-1 beta (IL-1), and IL-12 disrupt the TJ barrier in the intestine during inflammation, thereby increasing TJ permeability (128)

extended these findings to patients with CKD and obesity without T2D, in a trial that demonstrated a substantial reduction in UACR by 52.1% over 24 weeks with semaglutide 2.4 mg weekly, compared to a 7.4% increase in the placebo group [101]

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The Precision Peptide Genetic Test identifies variants in GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313 that may correlate with medication tolerance, weight loss response patterns, and side effect susceptibility

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