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When it becomes congested with triglycerides, your entire metabolism slows

and the interplay between the endoplasmic reticulum and actin to drive the contraction of the Drp1 protein to reduce the molecular spacing, leading to the rupture of the OMM and IMM and ultimately triggering mitochondrial fission (Giacomello et al., 2020

In fact, theres a popular approach to eating carnivore that calls for consuming only steak, water, and salt