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Furthermore, the heterogeneity in responses found across different transgenic AD mouse modelssome of which exhibit no discernable effect on A plaque burden (174), highlights the underlying complexity of the illness and implies a need for more personalized, precision-based therapy methods (175)

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In mice fed an HFD, B lymphocytes from mesenteric adipose tissue showed a tendency to migrate toward the liver and were proposed to contribute to the hepatic inflammatory response (170)