Activated M1 (or pro-inflammatory) microglia are part of an inflammatory cascade that includes upregulation of pro-inflammatory genes, release of pro-inflammatory cytokines, and generation of ROS, which may, under prolonged conditions, contribute to the neuroinflammation observed in AD brain [97]
If you feel strong or long-lasting side effects, or if they worsen, contact your healthcare provider right away
AOD-9604 has more clinical data behind it, including human trials and FDA GRAS status
Effects of GLP-1RAs on oxidative stress and mitochondrial function In patients with diabetes, chronic hyperglycemia can lead to excessive production of ROS and consequent imbalance in redox status in brain tissues, which may play an important role in the pathogenesis of ischemic stroke [85]
Pro Tip: Always track your energy and focus patterns over weeks, not just days