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Many patients report: Nausea Mild stomach discomfort Constipation or diarrhea Occasional fatigue These effects are usually most noticeable when you first start the medication or when your dose increases

That origin story matters because it makes MOTS-C part of a relatively new class of compounds called mitochondrial-derived peptides (MDPs)

Despite tirzepatide producing substantially greater average weight loss, it does not carry a meaningfully higher gastrointestinal burden in these pooled analyses

The pain was getting less, I was sleeping again, and starting to lift weights again

Those with severe gastrointestinal conditions, including gastroparesis: Given the drug's effects on gastric motility, individuals with gastroparesis or other severe upper gastrointestinal disorders may experience worsening symptoms