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Evidence from GH-transgenic mice

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The DPP-4 enzyme functions as a dimer, composed of two copies of the same protein (Figure 3).Saxagliptin is a substrate-like inhibitor of DPP-4, hence it inhibits DPP-4 by forming a covalent but reversible complex

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Deber , University of Toronto, Hospital for Sick Children Svetlana Mojsov , The Rockefeller University

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