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In a highdose semaglutide trial (7.2 mg weekly), participants lost about 20.7% of body weight in 72 weeks, with a substantial portion achieving up to 25% weight loss

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These drugs fall within two categories: human GLP-1 backbone agents (that is, albiglutide, dulaglutide, liraglutide and semaglutide) and exendin-4 backbone agents (that is, exenatide, lixisenatide and tirzepatidethe latter activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors) 1

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