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In septic lung injury, elevated lactate levels exacerbate alveolar epithelial cell ferroptosis through lactylated histone H3 lysine 18 (H3K18la)-mediated upregulation of METTL3, which enhances m6A modification of ACSL4, ultimately contributing to the development of acute respiratory distress syndrome (82)

Liposomal lactoferrin might act more effectively than conventional lactoferrin in the intestinal site, which is regarded as an active site of orally administered lactoferrin.

For example, high proteolytic sensitivity of casein was reported by McMeekin in 1952 (McMeekin, 1952)

2020;5:CD004192

GCLM: Glutamate-cysteine ligase modifying subunit