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Explanations for this excess of men have been attributed to possible protective hormonal factors in women, the increased likelihood of men being exposed to putative risk factors, and the under recognition of older women in some population registries (Wijesekera and Leigh 2009)

Prostaglandin E2 inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling

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It helps inhibit the production of melanin, resulting in a more even skin tone and reduced hyperpigmentation