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In neonates and young infants, particularly those who are jaundiced, premature or have conditions causing haemolysis (such as G6PD deficiency), this displacement could theoretically increase the risk of kernicterus a rare but serious form of brain damage caused by very high levels of unconjugated bilirubin

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Glucagon-like peptide-1 (GLP-1) analogs alter the activity of hypothalamic neurons in the arcuate nucleus, which are directly associated with eating behavior, thereby increasing satiety and reducing energy intake, leading to weight loss [11, 12]