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The result is that many people starting these medications are caught off guard by how they feel in the early weeks, leading some to stop treatment prematurely when the side effects were actually manageable and temporary, and others to push through symptoms that warranted medical attention

Peer review Peer review information Nature Reviews Endocrinology thanks Roger Adan, Ya-Xiong Tao and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Losing a significant amount of weight alters how the body distributes pressure across the spine

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and Imke Smit for help with data visualisation and statistical analysis