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In cultured pulmonary endothelial cells in vitro, carnitine can effectively reduce the apoptosis, damage to migration and obstruction of angiogenesis caused by hyperoxia, resulting in improvements in endothelial cell dysfunction and persistent lung injury under hyperoxic conditions [308]
Given uncertainty about tirzepatide's dual GIPR/GLP-1R agonism in cocaine paradigms, which characteristically show greater response variability than alcohol models, we used n = 710 for between-subjects experiments (locomotor activity, CPP, microdialysis) to maintain adequate power, accounting for 10-20% exclusions from misplaced microdialysis probes
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