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The macroscopic EC 50 (glutamate) for wild-type receptors was calculated to be 9.5 mM while it was measured to be 7.2 mM (Asn 247, *P = 0.0142)

Notably, acute stress was found to increase NMDAR- and AMPAR-mediated synaptic currents in PFC pyramidal neurons [27, 28], while chronic stress attenuates acute stress-evoked increases in extracellular glutamate [29]