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( Behavioural Neuroscience , 2008) In a frequently cited rat study, animals exposed to artificial sweeteners consumed more calories and gained more weight than animals whose sweet taste consistently predicted calories

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The secondary endpoints include achievement of 20% weight reduction, relative change in body weight, change in waist circumference, change in HbA1c, change in systolic blood pressure, change in the quality of life (IWQOL-Lite-CT), and change in short-form physical functioning score (SF-36v2)