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It is important to distinguish between classical treatments, which are well-established and commonly used in clinical practice such as L-DOPA, catechol-O-methyltransferase inhibitors, monoamine oxidase inhibitors, dopamine agonists, amantadine, and deep brain stimulation, novel treatments, which are still in the experimental or research stage, show promise as potential future therapeutic approaches such as stem cell therapy, graft assisted neural reconstruction, novel targets for disease modification, neurotrophic factors, and cannabinoids

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