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J Enzyme Inhib Med Chem 31(6):15311539 [DOI] [PubMed] [Google Scholar] Sujeck A, Gabrielska J, Grudzinski W, Borc R, Mazurek P, Gruszeski W (1999) Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects

Turnover from the retinol side, firmness signaling from the peptide side

They are often formed during the oxidation of lipids, proteins, and DNA, contributing to cellular damage and disease progression

HIF-1 forms a heterodimer with HIF-1 in the cytoplasm, translocates into the nucleus, and binds specific HREs on DNA, where it acts as a transcription factor for the downstream target gene VEGF ( Figure 3E )

Our aim is not to produce a list of defective pathways but to identify common patterns/pathways which may underpin a common etiology in these three conditions