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Route of Administration How a peptide is delivered dramatically affects how long it stays in the body: Subcutaneous injection : slower absorption, longer duration Intramuscular injection : faster peak concentration, moderate duration Oral and intranasal peptides : often rapidly broken down, requiring protective technologies or higher doses For example, oral BPC-157 may work primarily through gut-localized pathways, while injectable versions may provide broader systemic benefits

Science 365 , 6569 (2019)

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Moreover, different risk factors would influence the efficacy of supplements