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*Correspondence: Changgang Sun, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

It is more frequently diagnosed in women than in men, with a ratio of approximately 2:1

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The absence of labelling in vacuoles demonstrates that GSH-metal complexes, which are not recognized by the present immunohistochemical approach, are sequestered to this compartment after complexation in the cytosol

Tirzepatide arrived first, delivering unprecedented results in the SURMOUNT clinical trials and earning FDA approval as Zepbound