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Triple agonists will potentially be appropriate for patients with severe obesity requiring maximum intervention, those who havent responded adequately to dual agonists, patients willing to participate in clinical trials under strict medical supervision, and individuals who have plateaued on current therapies

Non-GLP-1 peptides work more gradually but preserve and in many cases improve lean muscle mass, making them a different tool with a different ideal patient

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Obese individuals often have microbiomes that increase energy extraction and fat accumulation