One of the hottest classes of drugs in the world owes part of its origin story to a weird desert lizard with a venomous bite and a prehistoric-looking face
Many of the examples that follow flow from this pre-pandemic relationship
ScGrx7 is particularly suited for unbiased kinetic and mechanistic studies because of its high activity, the absence of ironsulfur clusters in enzyme preparations and the lack of additional cysteine residues 11 (glutaredoxins with two or more cysteine residues have complex kinetics because of alternative redox states and reactions 10,12,14,17,30,31,32,33 )
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Sletten et al., 2018), including cardiac hypertrophy, fibrosis, gap junction remodeling, and myocardial injury (Shenasa et al., 2015