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4 weeks Minimum interval between dose increases 2mg to 12mg Phase 2 dose range (Jastreboff 2023) ~12 weeks Time to reach 12mg on standard protocol 24.2% Weight loss at 12mg, 48 weeks (Phase 2) Investigational Drug Warning Retatrutide (LY3437943) is not FDA-approved as of April 2026

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Medicare (Part D and Medicare Advantage) : For Medicare beneficiaries, coverage depends on the prescribed indication: For OSA: Zepbound received FDA approval in December 2024 to treat moderatetosevere OSA in people with a body mass index (BMI) of 30 or higher

However, patient reviews report variable experiences

Pain, prevalent in 3079% of patients, often necessitates analgesics, with chronic pain linked to poor functional status