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Animal studies also suggest that TMAO can impair glucose tolerance and exacerbate insulin resistance via inflammatory pathways [9]

95 g Fmoc-Gly-2-CTC Resin (20 mmol) with a degree of substitution of 0.211 mmol/g was weighed and swelled for 30 min with DMF, followed by sequentially coupling according to the amino acid sequence of Semaglutide with 2-5 equivalents of amino acid feeds and condensing with DIC+A or B+A+C, until the resin was detected to be transparent with ninhydrin, wherein A was HOBt or HOAt

Lipids Health Dis (2010) 9:15

Miyauchi, A

Lipoprotein apheresis is an optimal therapeutic option to reduce increased Lp(a) levels