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So, again, a lot of unknowns.
Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility
Potential gastrointestinal side effects include constipation and, rarely, fat malabsorption
For example, Roman and Innerbody Labs are the only two to offer T boosters that include copper as an offset to zinc, which has been shown to deplete copper levels.2 The top supplements in this guide may have certain ingredients that pose some risks, such as ashwagandhas potential influence over thyroid hormone levels,16 but those risks are either extrapolated from related data or currently only exist as case studies
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