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According to Global Cancer Observatory (GCO), colorectal cancer ranked as the fourth most prevalent malignancy worldwide in 2022, while stomach cancer and oral cancer ranks sixth and 17th respectively

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(33), treatments with Panobinostat (85 nM) and Valproic acid (VPA, a class I HDACi, 1.5 mM) decreased the mRNA expression of genes related to fibronectin, ACTA2 (actin), and COL1A1 (collagen)