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Glutathione-S-transferase catalyzes the conjugation of NAPQI with GSH, forming APAP-GSH adducts, 9,10 which are further metabolized into nontoxic thiolate and cysteine molecules, including adducts of cysteamide, glycine/cysteine, and N-acetyl-L-cysteine

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"All of this information suggests that these agents should be used with care and only among patients at greatest risk of poor health or obesity-related complications that have been appropriately counselled about their risks," Ward said

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Figure 3g summarizes the maximal saturation levels of all six metabolites