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Neuroprotective efficacy of thymoquinone against amyloid beta-induced neurotoxicity in human induced pluripotent stem cell-derived cholinergic neurons

3.1.2 Clinical manifestations of mutual influence The comorbidity of chronic constipation and depression leads to complex clinical presentations, with the two conditions mutually influencing each other to form a vicious cycle that significantly impairs quality of life

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In parallel, mitochondrial fragmentation and stress signaling may alter the plasma membrane lipid microenvironment and reduce the efficiency of membrane protein insertion, thereby compromising OCTN2 anchoring and stability within membrane microdomains [114]