As circadian rhythms are prevalent within physiological processes within the gut [8], there is the potential for some time-of-day variability in the absorption of orally administered drugs and in the speed of gastric emptying following a meal [8, 9]
So, part of the slow digestion strategy to sustain GLP-1 secretion is dietary fiber to slow down the digestion of nutrients
A previous pharmacovigilance study based on FAERS conducted an analysis of the potential risk between GLP-1RA and tumors and provided new real-world evidence for oncology safety information of GLP-1RA [Reference Yang, Lv, Yu, Mei, Xiang and Zhao12]
GLP-1(7-37) and GLP-1(7-36) amide both circulate in similar amounts and have equivalent bioactivity
These include: Nausea Diarrhoea Vomiting Constipation Abdominal pain Indigestion or heartburn Fatigue These side effects are typically mild to moderate in severity and tend to decrease over time as the body adapts to the medication