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Outcomes Primary and Secondary Outcome Patients in the semaglutide study arm experienced a significantly lower rate of the primary outcome (cardiovascular composite end-point) (6.5% vs 8.0%, HR 0.80 (95% CI 0.72-0.90) No significant difference in rates of cardiac death (HR 0.85, 95% CI 0.71-1.01) however significantly lower rates of heart failure (HR 0.82, 95% CI 0.71-0.96) and all-cause mortality (HR 0.81, 95% CI 0.71-0.93) Adverse Events Rates and types of adverse events were fairly similar between control and intervention groups Permanent premature discontinuation of semaglutide or placebo occurred in 2351 patients (26.7%) in the semaglutide group and 2078 (23.6%) in the placebo group In obese and overweight patients with cardiovascular comorbidities but without diabetes, treatment with weekly semaglutide was superior to placebo in reducing the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke at a mean follow-up of 39.8 months

PlexusDx's Precision Peptide Genetic Test doesn't predict rebound with certainty, but it identifies genetic variants (GLP1R rs6923761, FTO rs9939609, MC4R rs17782313, GIPR rs1800437) that influence appetite sensitivity and metabolic rate

10.1016/j.brainres.2003.09.022 39

Anaphylaxis, though rare with tirzepatide, constitutes a medical emergency requiring immediate medical attention

It resolves as the medication absorbs over the following hours