The reality check: the FDA does not consider it a legal cosmetic or dietary ingredient, and there is real concern that long-term use raises the risk of melanoma (skin cancer) the opposite of what most people assume a tan in a vial would do for skin safety (WebMD)
N Engl J Med 2023;389(24):2221-2232
Dermalogica Map-15 Regenerator: Water/Aqua/Eau, Glycerin, Silica, Magnesium Ascorbyl Phosphate, Phospholipids, C9-15 Fluoroalcohol Phosphate, Hydrogenated Lecithin, Sodium Hyaluronate, Glucosamine HCl, Algae Extract, Yeast Extract, Saccharide Isomerate, Camellia Sinensis Leaf Extract, Nelumbo Nucifera Flower Extract, Saccharide Hydrolysate, Magnesium Aspartate, Glycine, Alanine, Creatine, Polymethylsilsesquioxane, Silica Dimethyl Silylate, Silica Silylate, Vinyl Dimethicone/Methicone, Silsesquioxane, Dimethicone/Vinyl Dimethicone Crosspolymer, Urea, Ethylhexylglycerin, Hexylene Glycol, Caprylyl Glycol, Sorbic Acid, Potassium Sorbate, Propylene Glycol, Sodium Citrate, Phenoxyethanol
The regulatory environment for HIMS had already been difficult in early 2026
NMN is well absorbed in the gut, enters the bloodstream, and can cross directly into cells, where its quickly transformed into NAD+
