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Patients with CS show phenotypical characteristics including moon face, facial plethora, striae rubrae, supraclavicular and dorsal fat pads (86) and several comorbidities including DM, visceral obesity dyslipidaemia, cardiovascular disease, osteoporosis and vertebral fractures, infections and neuropsychiatric disorders, which can sometimes persist even after the disease is cured and contribute to increased mortality, compared to the general population (87, 88)

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Triggers production of collagen, elastin, and glycosaminoglycans directly counteracting the accelerated collagen loss of menopause