upset stomach with semaglutide Frontiers Patel it Like it is:

Persistent acid reflux that worsens rather than improves as your body adjusts to tirzepatide could indicate thyroid overmedication rather than a direct GLP-1 effect

Variants in GLP1R (the GLP-1 receptor itself), GIPR (the GIP receptor particularly relevant for tirzepatide given its dual GIP/GLP-1 mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

Ongoing dose adjustments tailored to your lifestyle

Terushkin V, Brodland DG, Sharon DJ, Zitelli JA

Athletes, especially endurance athletes, are more likely to experience gastrointestinal complaints such as nausea, vomiting, diarrhoea, abdominal pain and constipation when taking semaglutide