As results were already strongly statistically significant with these initial values, we did not add additional mice to the study under the principle of reduction in animal experiments [34]
In murine models of metabolic syndrome and diet-induced obesity, SLU-PP-332 reduces fat mass, improves lipid parameters, and remodels liver steatosis signatures while shifting respiratory exchange ratio toward greater lipid use
Free Radic Biol Med 180(20):112 Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
Available from: Wang Z, Wang S, Xu Q, Kong Q, Li F, Lu L, et al
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