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[1] Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations

Current Clinical Evidence for GLP-1 Use in Prader-Willi Syndrome Published case series and small observational studies suggest that semaglutide and tirzepatide may reduce appetite and promote weight loss in PWS patients

The LEADER trial (liraglutide) and SUSTAIN-6 trial (semaglutide) demonstrated cardiovascular risk reduction over multi-year follow-up periods (approximately 3.8 years and 2.1 years, respectively)

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Dayyani et al