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In a subanalysis of SURPASS-3, tirzepatide 10 and 15 mg resulted also in a relative reduction in liver fat content by 4047% compared to 11% with insulin glargine at 52 weeks [44]

f , Relative fold change of growth for Huh7 cells treated with indicated concentrations of R162 and -KG for 72 h

The oxidative branch of the pentose phosphate pathway (PPP), driven primarily by the enzymes glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), continues to serve as the dominant metabolic source of NADPH in most cells [42]

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