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Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease

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Cells were incubated at room temperature for a further 2 h and stimulated with 10 nM GLP-1 or GIP in HEPES-buffered saline (HBSS) containing 107 mM NaCl, 6 mM KCl, 1.2 mM MgSO 4 , 2 mM CaCl 2 , 1.2 mM KH 2 PO 4 , 20 mM HEPES, and 5.5 or 16.7 mM glucose at pH 7.4

Genital melanosis, also known as vulvar lentiginosis and vulvar melanotic macules, is a benign lesion characterized by macular pigmentation that can involve cutaneous or mucosal sites